Flaviana Bianco
Flaviana Bianco is a Medical Doctor and Child and Adolescent Pediatric Neurologist, currently working as Medical Director of the day-care center and dedicated ambulatory for Autism at Fondazione Oltre le Parole in Pescara and Chieti, Italy. She holds a PhD in Developmental Neuroscience from the Università Cattolica del Sacro Cuore in Rome and has extensive clinical experience in neurodevelopmental disorders, with a particular focus on Autism Spectrum Disorder, ADHD and neuromuscular diseases. Her professional approach integrates clinical neuropsychiatry, psychopharmacology and evidence-based behavioral interventions within a multidisciplinary framework aimed at improving functioning and Quality of Life. She completed advanced training in behavioral psychopharmacology for neurodevelopmental disorders and a postgraduate Master’s degree in Healthcare Management. She has served as lecturer in university and postgraduate courses and regularly participates in national scientific meetings on autism, neurodevelopmental disorders and disability. She is author and co-author of numerous peer-reviewed scientific publications in the fields of child neuropsychiatry and neuromuscular disorders.
Presentation at the ABA International Conference 2027
INTEGRATING PSYCHOPHARMACOLOGY AND BEHAVIOR ANALYSIS IN INTELLECTUAL AND DEVELOPMENTAL DISABILITIES
A synergistic pathway toward better quality of life
Abstract:
Challenging behaviors in people with autism spectrum disorder (ASD) and intellectual disability (ID) cannot be adequately understood—or treated—when they are reduced to isolated psychiatric symptoms. They may serve communicative, socio-environmental, or regulatory functions and may also represent expressions of physical or psychological distress. Diagnostic interpretation is further complicated by intellectual distortion, psychosocial masking, cognitive disorganization, and amplification of habitual behavior. Psychopharmacology should therefore not be conceived as an alternative to behavioral assessment, but as one component of an integrated, person-centered clinical pathway.
The presentation illustrates this approach through clinical cases in which systematic behavioral observation, functional and adaptive assessment, physiological measures, and longitudinal data collection were combined with carefully monitored pharmacological interventions. Outcomes were evaluated not only through changes in the frequency, duration, or intensity of target behaviors, but also through clinically meaningful indicators of functioning and quality of life. The cases show how changes in psychopharmacological treatment can be interpreted more accurately when they are embedded within continuous behavioral measurement and ecological observation.
Keywords: psychopharmacology; behavior analysis; intellectual disability; autism spectrum disorder; challenging behavior; functional assessment; quality of life; multidisciplinary care.
SELECTED REFERENCES
- Wachtel LE, Hagopian LP. Psychopharmacology and applied behavioral analysis: tandem treatment of severe problem behaviors in intellectual disability and a case series. Isr J Psychiatry Relat Sci. 2006;43(4):265-274. PMID: 17338446.
- Newcomb ET, Hagopian LP. Treatment of severe problem behaviour in children with autism spectrum disorder and intellectual disabilities. Int Rev Psychiatry. 2018;30(1):96-109. doi:10.1080/09540261.2018.1435513.
- Minshawi NF, Hurwitz S, Morriss D, McDougle CJ. Multidisciplinary assessment and treatment of self-injurious behavior in autism spectrum disorder and intellectual disability: integration of psychological and biological theory and approach. J Autism Dev Disord. 2015;45(6):1541-1568. doi:10.1007/s10803-014-2307-3.
- McCracken JT, McGough J, Shah B, et al.; Research Units on Pediatric Psychopharmacology Autism Network. Risperidone in children with autism and serious behavioral problems. N Engl J Med. 2002;347(5):314-321. doi:10.1056/NEJMoa013171.
- Ward F, Tharian P, Roy M, Deb S, Unwin GL. Efficacy of beta blockers in the management of problem behaviours in people with intellectual disabilities: a systematic review. Res Dev Disabil. 2013;34(12):4293-4303. doi:10.1016/j.ridd.2013.08.015.
- London EB, Zimmerman-Bier BL, Yoo JH, Gaffney JW. High-dose propranolol for severe and chronic aggression in autism spectrum disorder: a pilot, double-blind, placebo-controlled, randomized crossover study. J Clin Psychopharmacol. 2024;44(5):462-467. doi:10.1097/JCP.0000000000001895.
- Craft M, Ismail IA, Krishnamurti D, et al. Lithium in the treatment of aggression in mentally handicapped patients: a double-blind trial. Br J Psychiatry. 1987;150:685-689. doi:10.1192/bjp.150.5.685.
- National Institute for Health and Care Excellence (NICE). Challenging behaviour and learning disabilities: prevention and interventions for people with learning disabilities whose behaviour challenges. NICE Guideline NG11. London: NICE; 2015.
